منابع مشابه
TREM2 and neurodegenerative disease.
To the Editor: Guerreiro et al.1 and Jonsson et al.2 (Jan. 10 issue) report an association between the single-nucleotide polymorphism (SNP) rs75932628 in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) (predicting an R47H substitution) and Alzheimer’s disease in persons of European ancestry. We and other members of the Alzheimer’s Disease Genetics Consortium assem...
متن کاملTREM2 and neurodegenerative disease.
To the Editor: Guerreiro et al.1 and Jonsson et al.2 (Jan. 10 issue) report an association between the single-nucleotide polymorphism (SNP) rs75932628 in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) (predicting an R47H substitution) and Alzheimer’s disease in persons of European ancestry. We and other members of the Alzheimer’s Disease Genetics Consortium assem...
متن کاملNeurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
Genetic variations in the myeloid immune receptor TREM2 are linked to several neurodegenerative diseases. To determine how TREM2 variants contribute to these diseases, we performed structural and functional studies of wild-type and variant proteins. Our 3.1 Å TREM2 crystal structure revealed that mutations found in Nasu-Hakola disease are buried whereas Alzheimer's disease risk variants are fou...
متن کاملTREM2 variants in Alzheimer's disease.
BACKGROUND Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expressed on myeloid cells 2 protein, have previously been associated with an autosomal recessive form of early-onset dementia. METHODS We used genome, exome, and Sanger sequencing to analyze the genetic variability in TREM2 in a series of 1092 patients with Alzheimer's disease and 1107 controls (the d...
متن کاملTREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types and mechanisms underlying TREM2's involvement in neurodegeneration remain to be established. Here, we report that TREM2 is up-regulated on myeloid cells surrounding amyloid deposits in AD mouse models and human AD tissue...
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ژورنال
عنوان ژورنال: Rinsho Shinkeigaku
سال: 2014
ISSN: 0009-918X,1882-0654
DOI: 10.5692/clinicalneurol.54.1122